Exposure to Ultraviolet Radiation Causes Dendritic Cells/Macrophages to Secrete Immune-Suppressive IL-12p40 Homodimers

Immune-Suppressive IL-12p40 Homodimers Dendritic Cells/Macrophages to Secrete Exposure to Ultraviolet Radiation Causes

Human Exposure to Filtered Solar Ultraviolet Radiation

The erythemal exposure due to filtered ultraviolet radiation has been evaluated with a dosimetric spectrum evaluator in a glass enclosure to simulate a sun-room with glass roof and walls, in a greenhouse and in a small and large car. The ratio expressed as a percent of the erythemal irradiances to the shoulder of a person in an upright position inside each of the environments to those measured ...

Neonatal exposure to solar simulated ultraviolet radiation leads to deviation of immune development

Exposure to ultraviolet radiation (UVR) during childhood reduces the likelihood of developing auto-immune disease, but increases the risk of developing melanoma. As immune suppression is likely to contribute to both of these alterations, we propose that exposure to UVR during the neonatal period modifies development of the immune system. To test this hypothesis, neonatal mice were exposed to a ...

Syncytial Virus Infection and Immune Responses to Respiratory IL-12p40 and IL-18 Modulate Inflammatory

IL-12p40 and IL-18 modulate inflammatory and immune responses to respiratory syncytial virus infection.

Respiratory syncytial virus-induced bronchiolitis has been linked to the development of allergy and atopic asthma. IL-12 and possibly IL-18 are central mediators orchestrating Th1 and/or Th2 immune responses to infection. To determine a possible role for IL-12 in regulating the immune response to acute respiratory syncytial virus infection, IL-12p40 gene-targeted (IL-12p40-/-) and wild-type mic...